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ONTOLOGY REPORT - ANNOTATIONS

Term:response to methotrexate
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Accession:GO:0031427 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.

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response to methotrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004624743:1,446,643...1,462,319
Ensembl chrNW_004624743:1,446,643...1,461,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15089
    response to stimulus 8165
      response to chemical 4456
        response to oxygen-containing compound 2043
          response to methotrexate 1
            cellular response to methotrexate 0
Path 2
Term Annotations click to browse term
  biological_process 15089
    response to stimulus 8165
      response to chemical 4456
        response to organic substance 2986
          response to organonitrogen compound 1280
            response to methotrexate 1
              cellular response to methotrexate 0
paths to the root